Product

Class

Target

Clinical Stage

Manufacturer

Abraxane

Microtuble inhibitor

Microtuble

Phase II

Abraxis BioScience

ABT-510

Antiangiogenic

Thrombospndin-1

Phase I

Abbott

ABX-EGF

Antibody

EGFR

Phase I

Amgen and Abgenix

Affinitak

Antisense

Proteins Kinase C-alpha

Phase III

(NSCLC*)

Isis Pharmaceuticals

Almita

Antimetabolite

Dihydrofolate reductase

Market

Eli Lilly

Avastin

Antibody

VEGFR

Phase III

(NSCLC)

Genentech

BLP25

Vaccine

MUC1 Peptide

Phase II

(NSCLC)

Biomira

BMS-275291

Antiangiogenic

Metallproteinase

Phase II

Celltech

EP-2101

T cells

T cells

Phase II

Epimmune

Epothilone

Tubulin inhibitor

Microtubulin

Phase II

Bristol-Myers Squibb and Kosan Biosciences

Ethynylcytidine

RNA polymerase inhibitor

RNA synthesis

Phase II

GlaxoSmithKline

Gemzar

Nucleoside analogue

DNA replication

Market

(NSCLC)

Eli Lilly

HuN901-DM1

Antibody

DM1

Phase I

ImmunoGen

IMC-BEC2

Antibody

GD3

Phase III

ImClone

Iressa

Tyrosine kinase inhibitor

EGFR

Market

AstraZenca

Lung cancer vaccine

Vaccine

Immune system

Phase I

(NSCLC)

Corixa

Novantrone

Topoisomerase

Topoisomerase II

Market

(NSCLC)

OSI

Neovastat

Antiangiogenic

VEGFR

Phase III

(NSCLC)

Aetera Zentaris

Genasense

Small molecule

Bcl-2

Phase II

Aventis

Omnitarg

Antibody

HER dimerization inhibitor

Phase II

Genentech

OSI211

Topoisomerase

Topoisomerase I

Phase I

OSI

PDX (Pralatrexate)

Small molecule

Antifolates

Phase II

(NSCLC)

Allos

RSR13

(Efaproxiral)

Small molecule

Sensitize hypoxic area of tumors

Phase II

(NSCLC)

Allos

SGN-15

Antibody

Lewis^y-related antigen

Phase II

(NSCLC)

Seattle Genetics

Sutent

Kinase inhibitor

Phase II (NSCLC)

Pfizer

Tarceva

Small molecule

EGFR

Market

(NSCLC)

OSI and Roche

Taxol

Tubulin inhibitor

Microtubulin

Market

Bristol-Myers Squib

Taxotere

Tubulin inhibitor

Microtubulin

Market

Aventis

Theratope

Vaccine

Sialyl Tn

Phase III

Biomira

TriAb

Antibody

(anti-idiotype)

Human milk fat globule antigen

Phase II

(NSCLC)

Titan

TriGem

Antibody

GD2 ganglioside

Phase II (NSCLC)

Titan

Topetecan

Topoisomerase inhibitor

Topoisomerase I

Market

GlaxoSmithKline

Xyotax

Tubulin inhibitor

Microtubulin

Phase III

(NSCLC)

Cell Therapeutics