Regeneron Pharmaceuticals Inc.

777 Old Saw Mill River Road
Tarrytown, NY 10591

USA

Phone: (914) 347-7000
Fax: (914) 347-2113
Web Site: http://www.regeneron.com/

A. Company Profile

Regeneron (NASDAQ:REGN) is a biotech company with product portfolio including innovative treatments across a wide range of therapeutic areas. There are discovery and development programs in the field of oncology at Regeneron.

B. Products

Product Pipelines

1. Aflibercept

Aflibercept, VEGF Trap, is a unique fusion protein that binds all forms of vascular endothelial growth factor (VEGF), which is required for the growth of new blood vessels that are needed for tumors to grow and is a potent regulator. Aflibercept is a blocker of VEGF. It traps the VEGF being made by the tumor, stopping it from stimulating the VEGF receptor, and thus preventing the tumor from promoting blood vessel growth. As a consequence, the VEGF Trap inhibited the growth of tumors.