Vertex Pharmaceuticals, Inc.

130 Waverly Street
Cambridge, MA 02139

USA

Phone: (617) 444-6100
Fax: (617) 444-6680
Web Site: http://www.vpharm.com/

A. Company Profile

Vertex (NASDAQ:VRTX) is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for cancer.

B. Products

Product Pipelines

1. VX-680

VX-680 represents the first drug to stop tumors by targeting enzymes called Aurora kinases. Aurora kinases play an important role in mitosis, or the process of cell division, which is out of control in cancer patients. Aurora kinases have been identified as overly abundant in certain types of cancer, such as leukemia, colon cancer and breast cancer.

2. VX-944

VX-944 is a novel inosine monophosphate dehydrogenase (IMPDH) inhibitor.