Vical Inc.

10390 Pacific Center Courter
San Diego, CA 92121

USA

Phone: (858) 646-1100
Fax: (858) 646-1157
Email: aengbring@vical.com
Web Site: http://www.vical.com/

A. Company Profile

Vical (NASDAQ:VICL) is a biotech company and focuses on the products based on DNA delivery technologies for the prevention and treatment of life-threatening diseases, including cancer.

B. Products

Product Pipelines

1. Allovectin-7

Allovectin-7 is a DNA plasmid/lipid complex containing the DNA sequences encoding HLA-B7 and ࢸ microglobulin, which together form a Major Histocompatibility Complex, or MHC, Class I antigen. This type of antigen can trigger a potent immune response against foreign tissues, such as that seen in organ transplant rejections. Allovectin-7 is injected directly into tumors, and is designed to make malignant cells more visible to the immune system. The treatment may trigger an immune response against tumor cells, both locally and systemically, by enabling the immune system to recognize other features of tumor cells.

2. IL-2/EP

IL-2/EP is an enhanced delivery of plasmids encoding human IL-2