Product

Class

Target

Indication

Manufacturer

Abraxane

Microtubule inhibitor

Microtubule

Various tumors

Abraxis Biosciences

Alimta

Antimetabolite

Dihydrofolate reductase

Mesothelioma and lung cancer

Eli Lilly

Arimidex

Hormone

Aromatase inhibitor

Breast cancer

AstraZeneca

Aromasin

(Exemestane)

Hormone

Antiestrogen

Breast cancer

Pfizer

Avastin

Antibody

Vascular endothelial growth factor

Breast and colerectal cancers

Genentech

Bacillus Calmette-Guerin (BCG, TheraCys, ImmuCyst)

Immunomodulatory

Immune cells

Glioma

Organon and Aventis

Bexxar
(Iodine 131 Tositumomab)

Antibody

CD20

B-cell non-Hodgkin's lymphoma

GlaxoSmithKline

(Corixa)

Campath (Alemtuzumab)

Antibody

CD52

B cell chronic lymphocytic leukemia

Genzyme and Millennium

Casodex

Hormone

Anti-androgen

Prostate cancer

AstraZeneca

Cervarix

Vaccine

Human papillomavirus (HPV)

Cervical cancer

GlaxoSmithKline

Erbitux
(Cetuximab)

Antibody

Epidermal growth factor receptor

Colorectal cancer

Bristol-Myers Squibb and ImClone

Faslodex

Estrogen receptor antagonist

Estrogen receptor antagonist

Breast cancer

AstraZeneca

Femara

Hormone

Aromatase inhibitor

Breast cancer

Novartis

Gardasil

Vaccine

HPV

Cervical cancer

Merck

Gendicine

           Gene therapy

P53

Nasopharyngeal carcinoma

Sibiono GeneTech

Gleevec

(Imatinib mesylate)

Kinase inhibitor

Tyrosine kinase inhibitor

Chronic myelonic leukemia

Novartis

Gemzar

Antimetabolite

Nucleoside analogue

Pancreatic and non-small cell lung cancers

Eli Lilly

H101

Oncolytic virus

P53 pathway defective tumors

Head and neck cancers

Shanghai Sunway Biotech

Herceptin

(Trastuzumab)

Antibody

HER2

Breast cancer

Genentech

Hycamtin

Topoisomerase inhibitor

Topoisomerase I

Small cell lung cancer

GlaxoSmithKline

Intron A (Interferon alfa-2b)

Immunomodulatory

Immune cells

Various tumors

BiogenIdec

Iressa

Kinase inhibitor

EGFR tyrosine kinase inhibitor

Lung cancer

AstraZeneca

Irinotecan (Campto, Camptosar)

Topoisomerase inhibitor

Topoisomerase I

Colorectal cancer

Aventis, Pfizer, and Merck

Ixabepilone

Microtubule inhibitor

Microtubule

Breast cancer

BristolMyersSquibb

Mylotarg (Gemtuzumab ozogamicin)

Antibody

CD33

Acute myeloid leukemia

UCB (Celltech) and Wyeth

Nolvadex (Tamoxifen citrate)

Hormone

Estrogen antagonist

Breast cancer

AstraZeneca

Novantrone

Topoisomerase inhibitor

Topoisomerase II

Leukemia and prostate cancer

OSI

Ontak

Immunomodulatory

Immune cells

Persistent or recurrent cutaneous T-cell lymphoma

Ligand

Proleukin

Immunomodulatory

Immune cells

Melanoma and kidney cancer

Chiron

Revlimid

Immunomodulatory

Immune cells

Multiple myeloma and myelodysplatic

Celgene

Rituxan

(Rituximab)

Antibody

CD20

B-cell non-Hodgkin's lymphoma

BiogenIdec and Genentech

Sprycel

(Dasatinib, BMS354825)

Kinase inhibitor

Tyrosine kinase inhibitor

Chronic myelonic leukemia

Bristol-Myers Squibb

Sutent

(SU11248, Sunitinib Malate)

Kinase inhibitor

VEGFR tyrosine kinase inhibitor

GIST and kidney cancers

Pfizer

Tarceva

Kinase inhibitor

EGFR tyrosine kinase inhibitor

Non small cell lung cancer

Genentech and OSI

Taxotere

Microtubule inhibitor

Microtubule

 Various tumor

Sanofi-Aventis

Taxol

Microtubule inhibitor

Microtubule

Various tumor

Bristol-Myers Squibb

Thalomid and dexmethasone

Immunomodulatory

Immune cells

Multiple myeloma

Celgene

Torisel (Temsirolimus, CCI-779)

Cell cycle inhibitor

G1 to S phase transition

Kidney cancer

Wyeth

Tykerb (Lapatinib)

Kinase inhibitor

ErbB-2 and EGFR dual kinase inhibitors.

Breast cancer

GlaxoSmithKline

Vectibix

(ABX-EGF,  (Panitumumab)

Antibody

Epidermal growth factor receptor

Metastatic

Colorectal
cancers

Amgen

(Abgenix)

Velcade

Proteasome inhibitor

Proteasome

Multiple myeloma

Johnson and Johnson and Millennium

Xeloda

(Capecitabine)

Antimetabolite

Nucleoside analogue

Breast and colorectal cancers

Roche

Zevalin

(Yttrium-90, Ibritumomab tiuxetan

Antibody

CD20

B-cell non-Hodgkin's lymphomas

BiogenIdec

Zoladex

(Goserelin acetate)

Hormone

LHRH analogue

Breast and prostate cancers

AstraZeneca